Welage L S, Schultz R W, Schentag J J
Antimicrob Agents Chemother. 1984 Feb;25(2):201-4. doi: 10.1128/AAC.25.2.201.
The pharmacokinetics of ceftazidime were studied in 14 adult volunteers with different degrees of renal function. The elimination of ceftazidime was totally dependent on renal excretion. The clearance of ceftazidime ranged from 7.5 to 145.1 ml/min and correlated with both renal ceftazidime clearance and creatinine clearance (ClCR). It is recommended that 0.5 to 2.0 g of ceftazidime be given in extended dosages, with intervals dependent on the renal function of the patient. Patients with a ClCR of greater than 50 ml/min should be given ceftazidime every 8 h, those with a ClCR of 30 to 50 ml/min should be given the drug every 12 h, those with a ClCR of 15 to 30 ml/min should be given the drug once a day, and individuals with a ClCR of less than 15 ml/min should be given the drug on a day, and individuals with a ClCR of less than 15 ml/min should be given the drug on a 36- to 48-h regimen.
在14名具有不同程度肾功能的成年志愿者中研究了头孢他啶的药代动力学。头孢他啶的消除完全依赖于肾脏排泄。头孢他啶的清除率在7.5至145.1 ml/分钟之间，并且与肾脏头孢他啶清除率和肌酐清除率（ClCR）均相关。建议给予0.5至2.0 g头孢他啶延长剂量，间隔时间取决于患者的肾功能。ClCR大于50 ml/分钟的患者应每8小时给予头孢他啶一次，ClCR为30至50 ml/分钟的患者应每12小时给予该药物一次，ClCR为15至30 ml/分钟的患者应每天给予该药物一次，而ClCR小于15 ml/分钟的个体应采用36至48小时的给药方案给予该药物。
