Thurm R H, Alexander J C
Arch Intern Med. 1984 Apr;144(4):733-5.
Scleroderma is a disease of unknown cause characterized by interstitial fibrosis and vascular lesions in many organ systems. Renal failure, often associated with malignant hypertension, may ensue as a life-threatening component of this disorder. Activation of the renin-angiotensin-aldosterone system has been hypothesized as a cause of this complication. Captopril has been used in 23 patients with this condition. Of this group, 20 (87%) responded favorably with a decrease of the supine diastolic BP to less than 90 mm Hg and a reduction in the serum creatinine level in 14 patients. During long-term therapy (median, 29 months), 11 of the 23 patients continued to have a good clinical response while receiving captopril. Six patients died and six patients were alive after captopril therapy was discontinued. These data suggest that captopril is beneficial in the treatment of scleroderma renal crisis.
硬皮病是一种病因不明的疾病，其特征是多个器官系统出现间质纤维化和血管病变。肾衰竭常与恶性高血压相关，可能作为该疾病的一个危及生命的组成部分而出现。肾素-血管紧张素-醛固酮系统的激活被认为是这种并发症的一个原因。卡托普利已用于23例患有这种疾病的患者。在这组患者中，20例（87%）有良好反应，仰卧位舒张压降至90 mmHg以下，14例患者血清肌酐水平降低。在长期治疗期间（中位时间为29个月），23例患者中有11例在接受卡托普利治疗时仍有良好的临床反应。6例患者死亡，6例患者在停用卡托普利治疗后存活。这些数据表明卡托普利对硬皮病肾危象的治疗有益。
