Zolotarevskiĭ V B, Kogan E A
Arkh Patol. 1984;46(2):90-6.
On the basis of literature the markers of organ and tissue tumour specificity are reviewed. Signs of specific cell differentiation, similarity of tumour cells to the homologous cells of normal tissues are found electron-microscopically, histochemically (immunohistochemically and histoenzymochemically) in many organ-nonspecific tumours. Carcinoma cells with the ultrastructural features of organospecificity can be considered to be the cells-markers of the organ appurtenance of the tumor. Biological tumour markers (oncofetal antigens, ectopic hormones and enzymes) revealed until now in the serum and secretes of a tumour-bearing host, are not specific for a tumour of a single type. The search of criteria of tumour organospecificity (so-called biological, ultrastructural and histochemical markers) is necessary for precise tumour verification, determination of its histo- and cytogenesis and its primary location.
基于文献，对器官和组织肿瘤特异性标志物进行了综述。在许多器官非特异性肿瘤中，通过电子显微镜、组织化学（免疫组织化学和组织酶化学）发现了特定细胞分化的迹象，即肿瘤细胞与正常组织同源细胞的相似性。具有器官特异性超微结构特征的癌细胞可被视为肿瘤器官归属的细胞标志物。目前在荷瘤宿主的血清和分泌物中发现的生物肿瘤标志物（癌胚抗原、异位激素和酶）并非单一类型肿瘤所特有。寻找肿瘤器官特异性的标准（所谓的生物、超微结构和组织化学标志物）对于精确的肿瘤诊断、确定其组织和细胞发生及其原发部位是必要的。
