Becher R, Ohl S, Schaefer U W, Wendehorst E, Quiskamp F, Mahmoud H K, Schüning F, Schmidt C G
Blut. 1984 Apr;48(4):247-50. doi: 10.1007/BF00319818.
Clonal chromosomal evolution was observed in a 16-year-old boy suffering from Ph1-positive CML. An isodicentric Ph1 chromosome appeared 20 weeks after the initial diagnosis. At that time an allogeneic bone marrow transplantation was performed. Thereafter, during an observation period of more than 13 months, chromosome analyses showed neither the Ph1 chromosome nor the abnormal isodicentric variant. Close cytogenetic monitoring is suggested to reveal early unfavorable prognostic signs of the onset of blast crisis before it becomes evident in the bone marrow morphology.
在一名患Ph1阳性慢性粒细胞白血病的16岁男孩中观察到克隆性染色体进化。初诊20周后出现一条等臂双着丝粒Ph1染色体。当时进行了异基因骨髓移植。此后，在超过13个月的观察期内，染色体分析显示既没有Ph1染色体，也没有异常的等臂双着丝粒变体。建议进行密切的细胞遗传学监测，以在骨髓形态学出现明显变化之前揭示 blast 危机发作的早期不良预后迹象。
