Reynolds A K
Can J Physiol Pharmacol. 1984 Feb;62(2):183-98. doi: 10.1139/y84-029.
During the past decade, considerable progress has been made in our understanding of the mechanism underlying sensitization of the heart to the arrhythmogenic action of the catecholamines by hydrocarbon anesthetics. This review includes the following: a brief discussion on the concepts of the mechanics of induction of cardiac arrhythmia; recent studies on sensitization with special reference to the primary locus of this action and the principal mechanisms involved; and the contribution made by microelectrode studies on various types of cardiac tissue and the importance of cardiodynamic effects. In addition, atrioventricular conduction studies using bundle of His preparations are described. Drug interaction between anesthetic agents, muscle relaxants, and other drugs are discussed. Suggestions for future research and a section of summary and conclusions are included.
在过去十年中，我们对烃类麻醉剂使心脏对儿茶酚胺致心律失常作用敏感化的潜在机制的理解取得了相当大的进展。本综述包括以下内容：对心脏心律失常诱发机制概念的简要讨论；关于敏感化的近期研究，特别提及此作用的主要部位和涉及的主要机制；以及微电极对各种类型心脏组织的研究贡献和心脏动力学效应的重要性。此外，还描述了使用希氏束制剂进行的房室传导研究。讨论了麻醉剂、肌肉松弛剂和其他药物之间的药物相互作用。包括了对未来研究的建议以及总结和结论部分。
