D'Arcy P F
Drug Intell Clin Pharm. 1984 Apr;18(4):302-7. doi: 10.1177/106002808401800405.
Tobacco smoking may interact with the metabolism of a number of drugs. This has been demonstrated clearly in pharmacokinetic studies in animals and man. HOwever, tobacco smoking as a variant has been studied with relatively few clinically essential drugs and these studies do not always demonstrate a consistent effect of smoking. This review therefore not only records what data have emerged from pharmacokinetic or other studies, but it also attempts to determine whether such interactions have clinical significance. The main finding of this review is that, in the majority of examples, there is little evidence that there is a recognizable hazard from the interaction per se. The exceptions to this general conclusion are limited to four drugs: insulin, propoxyphene, propranolol, and theophylline preparations. With these drugs, there is some evidence of clinical importance of an interaction with tobacco smoking.
吸烟可能会与多种药物的代谢相互作用。这一点已在动物和人体的药代动力学研究中得到明确证实。然而，作为一种变量因素，针对吸烟与相对较少的临床必需药物之间的关系进行的研究并不总能证明吸烟具有一致的影响。因此，本综述不仅记录了药代动力学或其他研究中出现的数据，还试图确定此类相互作用是否具有临床意义。本综述的主要发现是，在大多数情况下，几乎没有证据表明这种相互作用本身会带来可识别的危害。这一普遍结论的例外情况仅限于四种药物：胰岛素、丙氧芬、普萘洛尔和茶碱制剂。对于这些药物，有一些证据表明吸烟与之相互作用具有临床重要性。
