Kjellström T, Elinder C G, Friberg L
Environ Res. 1984 Apr;33(2):284-95. doi: 10.1016/0013-9351(84)90025-2.
The definition of the "critical concentration" for cadmium is compared with the concepts used to establish this measure in some recent publications. The term has not been clearly defined on a population basis and this has given rise to certain confusion. Different groups of investigators therefore have arrived at different estimates of the "critical concentration" for cadmium in human kidney cortex. A new measure, the "population critical concentration" (PCC) with a clearly defined response rate, is suggested. A reanalysis of the published data indicates that the PCC-10 (10% response rate) for cadmium in kidney cortex is likely to be in the range 180-220 micrograms/g and the PCC-50 is likely to be about 25% higher.
将镉的“临界浓度”定义与近期一些出版物中用于确定该指标的概念进行了比较。该术语在总体层面上尚未得到明确界定，这引发了一定的混乱。因此，不同的研究小组对人肾皮质中镉的“临界浓度”得出了不同的估计值。本文提出了一种新的指标，即具有明确响应率的“总体临界浓度”（PCC）。对已发表数据的重新分析表明，肾皮质中镉的PCC-10（响应率为10%）可能在180 - 220微克/克范围内，而PCC-50可能高出约25%。
