山梨醇脱氢酶是一种锌酶。
Sorbitol dehydrogenase is a zinc enzyme.
作者信息
Jeffery J, Chesters J, Mills C, Sadler P J, Jörnvall H
出版信息
EMBO J. 1984 Feb;3(2):357-60. doi: 10.1002/j.1460-2075.1984.tb01811.x.
Abstract
Evidence is given that tetrameric sorbitol dehydrogenase from sheep liver contains one zinc atom per subunit, most probably located at the active site, and no other specifically bound zinc or iron atom. In alcohol dehydrogenases that are structurally related to sorbitol dehydrogenase, more than one zinc atom per subunit can complicate investigations of zinc atom function. Therefore, sorbitol dehydrogenase will be particularly valuable for defining the precise roles of zinc in alcohol and polyol dehydrogenases, and for establishing correlations of structure and function with other important zinc-containing proteins.
摘要
有证据表明，来自羊肝的四聚体山梨醇脱氢酶每个亚基含有一个锌原子，极有可能位于活性位点，且不存在其他特异性结合的锌或铁原子。在结构上与山梨醇脱氢酶相关的醇脱氢酶中，每个亚基不止一个锌原子会使锌原子功能的研究变得复杂。因此，山梨醇脱氢酶对于确定锌在醇脱氢酶和多元醇脱氢酶中的精确作用，以及建立结构与功能与其他重要含锌蛋白质之间的相关性将具有特别重要的价值。
相似文献
1
Sorbitol dehydrogenase is a zinc enzyme.山梨醇脱氢酶是一种锌酶。
EMBO J. 1984 Feb;3(2):357-60. doi: 10.1002/j.1460-2075.1984.tb01811.x.
2
Characteristics of alcohol/polyol dehydrogenases. The zinc-containing long-chain alcohol dehydrogenases.醇/多元醇脱氢酶的特性。含锌的长链醇脱氢酶。
Eur J Biochem. 1987 Sep 1;167(2):195-201. doi: 10.1111/j.1432-1033.1987.tb13323.x.
3
Alcohol and polyol dehydrogenases are both divided into two protein types, and structural properties cross-relate the different enzyme activities within each type.乙醇脱氢酶和多元醇脱氢酶都分为两种蛋白质类型，并且结构特性使每种类型中的不同酶活性相互关联。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4226-30. doi: 10.1073/pnas.78.7.4226.
4
Extensive variations and basic features in the alcohol dehydrogenase-sorbitol dehydrogenase family.乙醇脱氢酶-山梨醇脱氢酶家族的广泛变异和基本特征
Eur J Biochem. 1984 Apr 2;140(1):17-23. doi: 10.1111/j.1432-1033.1984.tb08061.x.
5
Alcohol and polyol dehydrogenases.乙醇脱氢酶和多元醇脱氢酶。
Pharmacol Biochem Behav. 1983;18 Suppl 1:67-71. doi: 10.1016/0091-3057(83)90149-1.
6
Properties of sorbitol dehydrogenase and characterization of a reactive cysteine residue reveal unexpected similarities to alcohol dehydrogenases.山梨醇脱氢酶的特性及一个活性半胱氨酸残基的表征揭示了与醇脱氢酶意想不到的相似性。
Eur J Biochem. 1981 Nov;120(2):229-34. doi: 10.1111/j.1432-1033.1981.tb05693.x.
7
8
Purification and characterization of human liver sorbitol dehydrogenase.人肝脏山梨醇脱氢酶的纯化与特性分析
Biochemistry. 1988 Mar 8;27(5):1622-8. doi: 10.1021/bi00405a035.
9
Molecular aspects of functional differences between alcohol and sorbitol dehydrogenases.乙醇脱氢酶和山梨醇脱氢酶功能差异的分子层面
Biochemistry. 1985 Dec 31;24(27):8005-12. doi: 10.1021/bi00348a025.
10
Zinc environment in sheep liver sorbitol dehydrogenase.绵羊肝脏山梨醇脱氢酶中的锌环境
Biochemistry. 1989 Sep 5;28(18):7257-62. doi: 10.1021/bi00444a017.
引用本文的文献
1
Purification and characterization of a novel medium-chain ribitol dehydrogenase from a lichen-associated bacterium Sphingomonas sp.从地衣相关细菌鞘氨醇单胞菌中纯化和表征一种新型中链赤藓糖醇脱氢酶
PLoS One. 2020 Jul 8;15(7):e0235718. doi: 10.1371/journal.pone.0235718. eCollection 2020.
2
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement.通过迭代隐马尔可夫模型细化，对 MDR 超家族中的中链脱氢酶/还原酶进行细分。
BMC Bioinformatics. 2010 Oct 27;11:534. doi: 10.1186/1471-2105-11-534.
3
Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily.中链和短链脱氢酶/还原酶基因与蛋白质家族：MDR超家族
Cell Mol Life Sci. 2008 Dec;65(24):3879-94. doi: 10.1007/s00018-008-8587-z.
4
Thionein/metallothionein control Zn(II) availability and the activity of enzymes.硫蛋白/金属硫蛋白控制锌（II）的有效性和酶的活性。
J Biol Inorg Chem. 2008 Mar;13(3):401-9. doi: 10.1007/s00775-007-0330-y. Epub 2007 Dec 12.
5
The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase.谷胱甘肽氧化还原对调节锌从金属硫蛋白向锌缺乏的山梨醇脱氢酶的转移。
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3483-8. doi: 10.1073/pnas.95.7.3483.
6
Woodward's reagent K inactivation of Escherichia coli L-threonine dehydrogenase: increased absorbance at 340-350 nm is due to modification of cysteine and histidine residues, not aspartate or glutamate carboxyl groups.伍德沃德试剂K使大肠杆菌L-苏氨酸脱氢酶失活：340 - 350纳米处吸光度增加是由于半胱氨酸和组氨酸残基的修饰，而非天冬氨酸或谷氨酸羧基的修饰。
Protein Sci. 1996 Feb;5(2):382-90. doi: 10.1002/pro.5560050223.
7
Molecular genetic analysis of the human sorbitol dehydrogenase gene.人类山梨醇脱氢酶基因的分子遗传学分析
Mamm Genome. 1995 Sep;6(9):645-52. doi: 10.1007/BF00352373.
8
Progressive sequence alignment and molecular evolution of the Zn-containing alcohol dehydrogenase family.含锌乙醇脱氢酶家族的渐进序列比对与分子进化
J Mol Evol. 1992 Jun;34(6):522-35. doi: 10.1007/BF00160465.
本文引用的文献
1
Bovine tryptophanyl-tRNA synthetase. A zinc metalloenzyme.
Eur J Biochem. 1981 Dec;120(3):511-7. doi: 10.1111/j.1432-1033.1981.tb05729.x.
2
Investigation of intermediates and transition states in the catalytic mechanisms of active site substituted cobalt(II), nickel(II), zinc(II), and cadmium(II) horse liver alcohol dehydrogenase.
Biochemistry. 1982 Jan 19;21(2):354-63. doi: 10.1021/bi00531a024.
3
Properties of sorbitol dehydrogenase and characterization of a reactive cysteine residue reveal unexpected similarities to alcohol dehydrogenases.山梨醇脱氢酶的特性及一个活性半胱氨酸残基的表征揭示了与醇脱氢酶意想不到的相似性。
Eur J Biochem. 1981 Nov;120(2):229-34. doi: 10.1111/j.1432-1033.1981.tb05693.x.
4
Simian liver alcohol dehydrogenase: isolation and characterization of isoenzymes from Macaca mulatta.猕猴肝脏乙醇脱氢酶：恒河猴同工酶的分离与特性研究
Biochemistry. 1981 Nov 10;20(23):6729-34. doi: 10.1021/bi00526a031.
5
Alcohol and polyol dehydrogenases are both divided into two protein types, and structural properties cross-relate the different enzyme activities within each type.乙醇脱氢酶和多元醇脱氢酶都分为两种蛋白质类型，并且结构特性使每种类型中的不同酶活性相互关联。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4226-30. doi: 10.1073/pnas.78.7.4226.
6
Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution.分辨率为2.9埃的马肝醇脱氢酶三斜三元复合物的结构。
J Mol Biol. 1981 Mar 15;146(4):561-87. doi: 10.1016/0022-2836(81)90047-4.
7
Substituent effects on the ionization step regulating desorption and catalytic oxidation of alcohols bound to liver alcohol dehydrogenase.取代基对调节与肝脏乙醇脱氢酶结合的醇类脱附和催化氧化的电离步骤的影响。
Eur J Biochem. 1981 Mar;114(3):555-63. doi: 10.1111/j.1432-1033.1981.tb05180.x.
8
Simian liver alcohol dehydrogenase: isolation and characterization of isoenzymes from Saimiri sciureus.松鼠猴肝脏乙醇脱氢酶：松鼠猴中同工酶的分离与特性分析
Biochemistry. 1981 Feb 17;20(4):856-61. doi: 10.1021/bi00507a031.
9
New human liver alcohol dehydrogenase forms with unique kinetic characteristics.具有独特动力学特性的新型人类肝脏乙醇脱氢酶形式。
Biochem Biophys Res Commun. 1981 Jan 15;98(1):122-30. doi: 10.1016/0006-291x(81)91878-7.
10
Purification and some properties of aldehyde reductases from pig liver.猪肝中醛还原酶的纯化及某些性质
Eur J Biochem. 1980 Apr;105(3):611-21. doi: 10.1111/j.1432-1033.1980.tb04539.x.
Zotero 插件