Kono T
Fed Proc. 1984 May 15;43(8):2256-7.
This article reviews the experimental data that support the translocation hypothesis of insulin action on glucose transport in adipocytes. According to this hypothesis, 1) most of the glucose transport mechanism in the basal (no insulin) form of fat cells is associated with an unidentified subcellular structure (the storage site), which is separated into the Golgi-rich fraction by centrifugation, and 2) the function of insulin is to induce translocation of the glucose transport mechanism from the above storage site to the plasma membrane. This translocation of the transport mechanism is reversible, dependent on metabolic energy, and independent of protein synthesis.
本文综述了支持胰岛素作用于脂肪细胞葡萄糖转运的转位假说的实验数据。根据这一假说，1）脂肪细胞基础状态（无胰岛素）下的大部分葡萄糖转运机制与一种未明确的亚细胞结构（储存位点）相关，该结构通过离心分离到富含高尔基体的部分中；2）胰岛素的作用是诱导葡萄糖转运机制从上述储存位点转位到质膜。这种转运机制的转位是可逆的，依赖于代谢能量，且与蛋白质合成无关。
