甲状旁腺功能减退症中的1,25-二羟胆钙化醇

1,25-dihydroxycholecalciferol in hypoparathyroidism.

作者信息

Davies M, Taylor C M, Hill L F, Stanbury S W

出版信息

Lancet. 1977 Jan 8;1(8002):55-9. doi: 10.1016/s0140-6736(77)91077-7.

Abstract

8 patients with hypoparathyroidism have been treated successfully with 1,25-dihydroxycholecalciferol (0-25-1-0 mug/day) for 4-24 mo. Normal serum-calcium levels were restored in all patients, but half the patients required supplementary oral calcium. Treatment reduced serum-phosphorus in all patients, but values remained high in 3, and the renal-tubular reabsorption of phosphate returned to normal in only 2 of the 8 patients. A comparison is made with the effects of oral therapy with massive amounts of calcium salts. The data obtained are discussed in relation to the probable mode of therapeutic action of 1,25-dihydroxycholecalciferol.

摘要

8例甲状旁腺功能减退患者用1,25 - 二羟胆钙化醇（0 - 25 - 1 - 0微克/天）成功治疗4 - 24个月。所有患者血清钙水平恢复正常，但半数患者需要补充口服钙剂。治疗使所有患者血清磷降低，但3例患者的血清磷值仍高，8例患者中仅2例的肾小管对磷的重吸收恢复正常。文中对大剂量钙盐口服治疗的效果进行了比较。结合1,25 - 二羟胆钙化醇可能的治疗作用方式对所得数据进行了讨论。