Blanchard K, Dandavino A, Nuwayhid B, Brinkman C R, Assali N S
Am J Obstet Gynecol. 1978 Mar 15;130(6):669-73. doi: 10.1016/0002-9378(78)90326-5.
The systemic and uterine hemodynamic effects of dopamine were studied in nonpregnant and near-term pregnant, unanesthetized, chronically instrumented sheep. Dopamine was administered by constant intravenous infusion in doses ranging from 2 to 40 microgram per kilogram per minute. A hypertensive effect was consistently observed when doses greater than 5 microgram per kilogram per minute were given. The rise in pressure was accompanied by a rise in the systemic vascular resistance and an increase in the cardiac output; the increment in the latter was greater in the pregnant than in the nonpregnant animals. Uterine blood flow increased consistently despite some rise in uterine vascular resistance; uterine fraction of cardiac output either remained unchanged or increased slightly. Venomotor construction, reflected by a rise in central venous pressure, occurred at all dose levels. These hemodynamic properties of dopamine may be explained partly on the basis of its combined beta- and alpha-mimetic action, as well as through redistributions of flows and resistances among various regional vascular beds.
在未麻醉、长期植入仪器的非妊娠和接近足月妊娠绵羊中，研究了多巴胺对全身和子宫血流动力学的影响。通过持续静脉输注给予多巴胺，剂量范围为每分钟每千克2至40微克。当给予大于每分钟每千克5微克的剂量时，持续观察到高血压效应。血压升高伴随着全身血管阻力升高和心输出量增加；后者在妊娠动物中的增加幅度大于非妊娠动物。尽管子宫血管阻力有所升高，但子宫血流量持续增加；心输出量的子宫部分要么保持不变，要么略有增加。在所有剂量水平下，均出现了以中心静脉压升高为表现的静脉收缩。多巴胺的这些血流动力学特性，部分可以基于其β和α模拟作用的组合，以及通过不同区域血管床之间的血流和阻力重新分布来解释。
