Cugini P, Salandi E, Menna P, Scavo D
Quad Sclavo Diagn. 1983 Mar;19(1):62-72.
This report describes the impulsive function of the RAAS investigated in obese and non-obese hypertensives as compared to obese and non-obese normotensives. The aim of the investigation was to clarify whether or not the hypertensive vascular disease accompanying the ponderal excess can be regarded as a well-defined pathophysiologic entity. Data obtained showed that the behavior of the RAAS in hypertensive obese patients is quite different from that of non-obese hypertensives and obese normotensives. Such a difference implies that hypertension of obese people is a biochemically distinguishable entity. This observation corroborates the concept that the clinical association of obesity-hypertension might be regarded as a syndrome with a proper nosographic dignity.
本报告描述了在肥胖和非肥胖高血压患者中研究的肾素-血管紧张素-醛固酮系统（RAAS）的冲动功能，并与肥胖和非肥胖血压正常者进行了比较。该研究的目的是阐明伴随体重过重的高血压血管疾病是否可被视为一种明确的病理生理实体。获得的数据表明，高血压肥胖患者中RAAS的行为与非肥胖高血压患者和肥胖血压正常者有很大不同。这种差异意味着肥胖人群的高血压是一种在生物化学上可区分的实体。这一观察结果证实了肥胖-高血压的临床关联可能被视为一种具有适当疾病分类尊严的综合征的概念。
