Juhan-Vague I, Vague P, Poisson C, Aillaud M F, Mendez C, Collen D
Thromb Haemost. 1984 Feb 28;51(1):97-8.
We have previously demonstrated that a short period of normoglycaemia obtained through an artificial pancreas in uncontrolled insulin-dependent diabetics improves parameters of the functional microangiopathy such as erythrocyte deformability and platelet aggregation. Because recently an immunoradiometric assay for tissue plasminogen activator (t-PA) was developed we measured t-PA levels in 18 uncontrolled insulin-dependent diabetics before and after 24 hr of normoglycaemia induced by insulin to look for a modification of endothelial cells function. After 24 hr of strict control, plasma free insulin levels rose significantly, total t-PA R-Ag, its active fibrin binding fraction and euglobulin fibrinolytic activity were significantly decreased. These results suggest a responsibility for insulin in the decrease in t-PA blood level and could explain at least partially the relation between hyperinsulinism, thrombosis and atherogenesis.
我们之前已经证明，通过人工胰腺使未得到控制的胰岛素依赖型糖尿病患者实现短时间的血糖正常化，可改善功能性微血管病变的参数，如红细胞变形能力和血小板聚集。由于最近开发了一种组织型纤溶酶原激活物（t-PA）的免疫放射分析方法，我们测定了18例未得到控制的胰岛素依赖型糖尿病患者在胰岛素诱导的血糖正常24小时前后的t-PA水平，以寻找内皮细胞功能的改变。严格控制24小时后，血浆游离胰岛素水平显著升高，总t-PA R-Ag、其活性纤维蛋白结合部分和优球蛋白纤溶活性显著降低。这些结果表明胰岛素与t-PA血液水平降低有关，并且至少可以部分解释高胰岛素血症、血栓形成和动脉粥样硬化之间的关系。
