Ohgawara H, Hirata Y
Tohoku J Exp Med. 1984 Feb;142(2):211-6. doi: 10.1620/tjem.142.211.
The prevalence of islet cell surface antibodies (ICSA) in patients with insulin-dependent (IDD), noninsulin-dependent (NIDD) or newly-diagnosed diabetes mellitus was studied. The antibodies were present in 14 (27%) of 15 IDD patients below the age of 30 years, and in 11 (12%) of 91 NIDD patients. Among 46 newly-diagnosed diabetic patients, (aged over 30 years), 14 (30%) were antibody-positive and had a fasting blood sugar exceeding 11 mmol glucose. The glucose tolerance after a standardized breakfast decreased in IDD or insulin-treated patients with ICSA compared to patients without antibodies. C-peptide was also lower in patients with circulating ICSA (xi CPR/xi BS during a standardized breakfast test 0.61 +/- 0.30 vs. 1.09 +/- 0.3 in IDD, 1.18 +/- 0.13 vs. 1.46 +/- 0.43 in the patients with insulin treatment). These results suggest that circulating ICSA be also present in some newly-diagnosed patients of over 30 years of age who require insulin treatment and who have an associated decreased glucose tolerance and C-peptide response.
我们研究了胰岛素依赖型糖尿病（IDD）、非胰岛素依赖型糖尿病（NIDD）或新诊断糖尿病患者中胰岛细胞表面抗体（ICSA）的患病率。在15例30岁以下的IDD患者中，有14例（27%）存在该抗体；在91例NIDD患者中，有11例（12%）存在该抗体。在46例新诊断的糖尿病患者（年龄超过30岁）中，14例（30%）抗体呈阳性，且空腹血糖超过11 mmol葡萄糖。与无抗体的患者相比，有ICSA的IDD患者或接受胰岛素治疗的患者在标准早餐后的糖耐量降低。循环ICSA患者的C肽水平也较低（在标准早餐试验期间，IDD患者的xi CPR/xi BS为0.61±0.30，而无抗体患者为1.09±0.3；接受胰岛素治疗的患者为1.18±0.13，而无抗体患者为1.46±0.43）。这些结果表明，在一些年龄超过30岁、需要胰岛素治疗、伴有糖耐量降低和C肽反应的新诊断患者中也存在循环ICSA。
