Heaton R W, Henderson A F, Dunlop L S, Costello J F
Br J Dis Chest. 1984 Apr;78(2):168-73.
The effect of pretreatment with prostaglandin F2 alpha (PGF2 alpha) on the bronchial sensitivity to histamine and methacholine has been studied in three groups of six normal subjects, and compared with the effect of citric acid aerosol as a non-specific stimulant of bronchial irritant receptors. Aerosols were generated by Wright's nebulizer and dose-response curves to histamine and methacholine constructed following preadministration of saline, prostaglandin F2 alpha or citric acid. Following prostaglandin F2 alpha pretreatment, the PC20 histamine fell from 12.9 mg/ml to 3.4 mg/ml (P less than 0.01), but the PC20 methacholine was unchanged. Citric acid was without effect. The results indicate that prostaglandin F2 alpha can increase bronchial sensitivity to inhaled histamine, possibly via a direct effect on the airway smooth muscle.
在三组每组六名正常受试者中研究了用前列腺素F2α（PGF2α）预处理对支气管对组胺和乙酰甲胆碱敏感性的影响，并与柠檬酸气雾剂作为支气管刺激感受器的非特异性刺激物的作用进行了比较。气雾剂由赖特雾化器产生，在给予生理盐水、前列腺素F2α或柠檬酸后构建组胺和乙酰甲胆碱的剂量反应曲线。前列腺素F2α预处理后，组胺的PC20从12.9毫克/毫升降至3.4毫克/毫升（P<0.01），但乙酰甲胆碱的PC20未改变。柠檬酸无作用。结果表明，前列腺素F2α可能通过对气道平滑肌的直接作用增加支气管对吸入组胺的敏感性。
