Renoux G
Biomed Pharmacother. 1983;37(9-10):433-40.
Thymus is widely thought as playing the central role in the control of T-cell differentiation. A review of the literature suggests a more general role is displayed by the thymus, envisioned as a part of a hypothalamo-hypophyseal-thymic axis to control the production of hormones and transmitters which, in turn, regulate immune function. Products of macrophages and lymphocytes interfere with the hypothalamus to modify behavior and immune response, in the presence of a foreign body. Brain neocortex controls thymic and extrathymic factors involved in T-cell differentiation.
胸腺被广泛认为在T细胞分化的控制中起着核心作用。对文献的回顾表明，胸腺发挥着更广泛的作用，被设想为下丘脑 - 垂体 - 胸腺轴的一部分，以控制激素和递质的产生，而这些激素和递质又反过来调节免疫功能。在存在异物的情况下，巨噬细胞和淋巴细胞的产物会干扰下丘脑，从而改变行为和免疫反应。大脑新皮质控制参与T细胞分化的胸腺和胸腺外因子。
