Fuhrmann K, Reiher H, Semmler K, Glöckner E
Exp Clin Endocrinol. 1984 Apr;83(2):173-7. doi: 10.1055/s-0029-1210327.
56 out of the 200 pregnant diabetic women admitted to our clinic between July 1981 and June 1983 had followed a pre-pregnancy metabolic intensive treatment programme. Most of these patients achieved near-normoglycemia: 87% or more of all their blood glucose readings before conception and in the early weeks of gestation were normoglycemic. The 56 patients were delivered of 57 babies, one of them suffering from fatal heart malformation. The 144 pregnant diabetics who were admitted to hospital only after eight weeks of pregnancy and had not had any special preconceptional metabolic control gave birth to 145 children, 9 of which presented congenital malformations: 3 of these were fatal another 3 were severe, and 3 were minor. These data are in line with our previously reported results on the years 1977-81. They stress the importance of a reasonably strict metabolic control, started well before conception, to prevent excess rates of congenital malformation.
1981年7月至1983年6月期间入住我们诊所的200名妊娠糖尿病妇女中，有56名遵循了孕前强化代谢治疗方案。这些患者中的大多数实现了接近正常血糖水平：在受孕前和妊娠早期，她们所有血糖读数的87%或更多为正常血糖。这56名患者共分娩了57名婴儿，其中1名患有致命性心脏畸形。144名仅在妊娠8周后才入院且未进行任何特殊孕前代谢控制的妊娠糖尿病患者，生下了145名儿童，其中9名出现先天性畸形：其中3例是致命的，另外3例严重，3例轻微。这些数据与我们之前报告的1977 - 1981年的结果一致。它们强调了在受孕前就开始进行合理严格的代谢控制以预防先天性畸形发生率过高的重要性。
