钙离子可保护细胞-基质黏附受体免受蛋白水解作用。免疫吸附和电印迹研究证据。
Calcium ions protect cell-substratum adhesion receptors against proteolysis. Evidence from immunoabsorption and electroblotting studies.
作者信息
Oppenheimer-Marks N, Grinnell F
出版信息
Exp Cell Res. 1984 Jun;152(2):467-75. doi: 10.1016/0014-4827(84)90648-7.
PMID:6373329
Abstract
An antibody preparation against BHK cell wheat germ agglutinin receptors (anti-WGA-R), which inhibits fibronectin-mediated cell adhesion, was characterized by immunoabsorption and electroblotting experiments. The results indicated that a 48 kD cell surface WGA-R receptor is protected from proteolysis by Ca2+ ions and is important in fibronectin-mediated cell adhesion.
摘要
一种针对BHK细胞麦胚凝集素受体（抗WGA-R）的抗体制剂，其可抑制纤连蛋白介导的细胞黏附，通过免疫吸附和电印迹实验对其进行了表征。结果表明，一种48 kD的细胞表面WGA-R受体受到Ca2+离子的保护而不被蛋白水解，并且在纤连蛋白介导的细胞黏附中起重要作用。
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