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钙离子可保护细胞-基质黏附受体免受蛋白水解作用。免疫吸附和电印迹研究证据。

Calcium ions protect cell-substratum adhesion receptors against proteolysis. Evidence from immunoabsorption and electroblotting studies.

作者信息

Oppenheimer-Marks N, Grinnell F

出版信息

Exp Cell Res. 1984 Jun;152(2):467-75. doi: 10.1016/0014-4827(84)90648-7.

DOI:10.1016/0014-4827(84)90648-7
PMID:6373329
Abstract

An antibody preparation against BHK cell wheat germ agglutinin receptors (anti-WGA-R), which inhibits fibronectin-mediated cell adhesion, was characterized by immunoabsorption and electroblotting experiments. The results indicated that a 48 kD cell surface WGA-R receptor is protected from proteolysis by Ca2+ ions and is important in fibronectin-mediated cell adhesion.

摘要

一种针对BHK细胞麦胚凝集素受体（抗WGA-R）的抗体制剂，其可抑制纤连蛋白介导的细胞黏附，通过免疫吸附和电印迹实验对其进行了表征。结果表明，一种48 kD的细胞表面WGA-R受体受到Ca2+离子的保护而不被蛋白水解，并且在纤连蛋白介导的细胞黏附中起重要作用。

相似文献

1
Calcium ions protect cell-substratum adhesion receptors against proteolysis. Evidence from immunoabsorption and electroblotting studies.钙离子可保护细胞-基质黏附受体免受蛋白水解作用。免疫吸附和电印迹研究证据。
Exp Cell Res. 1984 Jun;152(2):467-75. doi: 10.1016/0014-4827(84)90648-7.
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引用本文的文献

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J Cell Biol. 1985 Mar;100(3):721-6. doi: 10.1083/jcb.100.3.721.
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A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence.一种针对I型胶原蛋白的细胞表面受体复合物可识别精氨酸-甘氨酸-天冬氨酸序列。
J Cell Biol. 1987 Mar;104(3):585-93. doi: 10.1083/jcb.104.3.585.
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J Exp Med. 1985 Jul 1;162(1):157-70. doi: 10.1084/jem.162.1.157.
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Disialoganglioside GD2 distributes preferentially into substrate-associated microprocesses on human melanoma cells during their attachment to fibronectin.双唾液酸神经节苷脂GD2在人黑色素瘤细胞附着于纤连蛋白的过程中优先分布于与底物相关的微突起中。
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