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高催乳素血症女性的妊娠情况。

Pregnancy in hyperprolactinemic women.

作者信息

Ruiz-Velasco V, Tolis G

出版信息

Fertil Steril. 1984 Jun;41(6):793-805. doi: 10.1016/s0015-0282(16)47888-x.

Abstract

Pregnancy achieved in women who receive treatment to correct the secretory dysfunction of nontumoral HPRL or microprolactinomas requires close prenatal care, but generally its course does not vary from normal. When a macroprolactinoma is present, consequences of pregnancy are insignificant, provided the tumor has been previously treated or bromocriptine is given continuously during the pregnancy. On those rare occasions when symptoms of tumor growth appear during pregnancy, bromocriptine and dexamethasone effectively control such manifestations. Breast-feeding of the infant can be allowed, and a second pregnancy within a short term is not contraindicated. When a new pregnancy is not desired, nonhormonal contraceptive methods are advised. Patients with nontumoral HPRL and microadenomas require periodic checkups. Macroadenomas may be surgically excised, but longterm bromocriptine treatment also achieves good results and is highly recommended.

摘要

接受治疗以纠正非肿瘤性高泌乳素血症(HPRL)或微泌乳素瘤分泌功能障碍的女性成功怀孕后,需要密切的产前护理,但总体而言其孕期过程与正常情况并无差异。如果存在大泌乳素瘤,只要肿瘤先前已得到治疗或在孕期持续服用溴隐亭,怀孕的后果并不严重。在极少数情况下,孕期出现肿瘤生长症状时,溴隐亭和地塞米松可有效控制这些表现。可以允许对婴儿进行母乳喂养,短期内再次怀孕也无禁忌。如果不希望再次怀孕,建议采用非激素避孕方法。非肿瘤性HPRL和微腺瘤患者需要定期检查。大腺瘤可通过手术切除,但长期溴隐亭治疗也能取得良好效果,强烈推荐。

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