Wajchenberg B L, Leme C E, Lerario A C, Toledo e Souza I T, Rodbard H W, Rodbard D
Diabetes. 1984 May;33(5):455-9. doi: 10.2337/diab.33.5.455.
Studies of 125I -insulin binding to erythrocytes (RBC) from 5 patients with Cushing's disease were performed in an attempt to evaluate the insulin resistance in this disease. Five obese, nondiabetic patients and six normal subjects served as controls. Insulin resistance was present in both the obese, nondiabetic subjects and in the patients with Cushing's disease. Patients with Cushing's disease showed insulin resistance out of proportion to obesity, and of greater severity than in the obese subjects. As in previous studies, the insulin resistance of the obese subjects could be at least partially ascribed to a reduced number of receptors. In contrast, in our patients with Cushing's disease, no physiologically significant changes in the parameters of insulin-receptor interaction could be demonstrated. This suggests that the RBC insulin receptor is not involved in this type of insulin resistance.
对5例库欣病患者的红细胞（RBC）进行了¹²⁵I-胰岛素结合研究，以评估该疾病中的胰岛素抵抗。5例肥胖非糖尿病患者和6例正常受试者作为对照。肥胖非糖尿病受试者和库欣病患者均存在胰岛素抵抗。库欣病患者的胰岛素抵抗与肥胖不成比例，且比肥胖受试者更严重。与先前的研究一样，肥胖受试者的胰岛素抵抗至少部分可归因于受体数量减少。相比之下，在我们的库欣病患者中，未发现胰岛素受体相互作用参数有生理上显著的变化。这表明红细胞胰岛素受体不参与此类胰岛素抵抗。
