Teuber J, Meier S, Aigner K, Helmke K, Paul F, Federlin K
Immun Infekt. 1983 May;11(3):91-8.
CEA levels in serum are not reliable markers of tumors. In this paper a method for determination of this antigen for tissue sections is given. Histology, immunohistology and serum levels of CEA were compared. Tissue sections were obtained by surgical and endoscopic techniques. In several cases there was a discrepancy between serological and morphological results. Based on recent investigations elevated CEA levels might be only useful in reflecting a relapse of carcinoma of the colon. Immunohistological determinations were done by IFT and PAP-method. The results of both assay systems were comparable. CEA could be also detected in benign neoplasiogenic tissue, i.e. in tubular type of adenomatose polyps and in ulcerative colitis. Both diseases are known to become malignant at an high degree. By contrast no CEA could be detected in hyperplasiogenic polyps. Detection of CEA in malignant tissue might be useful for final classification of tumors. Occurrence of CEA in non malignant tissue should give rise to control in short regular intervals. Prospective studies might show the reliability of the CEA-bearing cells of non malignant tissue.
血清中的癌胚抗原（CEA）水平并非肿瘤的可靠标志物。本文给出了一种用于组织切片中该抗原的测定方法。对CEA的组织学、免疫组织学及血清水平进行了比较。组织切片通过手术及内镜技术获取。在一些病例中，血清学和形态学结果存在差异。基于近期研究，CEA水平升高可能仅有助于反映结肠癌的复发。免疫组织学测定采用间接荧光试验（IFT）和过氧化物酶抗过氧化物酶法（PAP法）。两种检测系统的结果具有可比性。在良性肿瘤性组织中也能检测到CEA，如管状腺瘤性息肉及溃疡性结肠炎组织。已知这两种疾病都有较高的恶变几率。相比之下，在增生性息肉中未检测到CEA。在恶性组织中检测CEA可能有助于肿瘤的最终分类。在非恶性组织中检测到CEA应定期进行短期监测。前瞻性研究可能会显示非恶性组织中携带CEA细胞的可靠性。
