Nervig R M, Cheville N F, Baetz A L
Am J Vet Res. 1978 Mar;39(3):523-5.
This is a report on the experimental infection of cattle with Leptospira interrogans serotype szwajizak. The principal clinical features in three 4-week-old Holstein-Friesian heifers intravenously inoculated were fever, listlessness, anorexia, weakness, and diarrhea. Szwajizak was isolated from the blood for the first 5 to 8 days after inoculation. Leptospires were recovered from kidneys, but not from liver, spleen, brain, or urine. Two of the 3 calves produced homologous agglutinins, with maximum serum titers of 1:80 and 1:160. The sera of the 2 calves that developed szwajizak agglutinins showed cross reactivity with wolffi and hardjo antigens. There were not significant differences of plasma and urine constituents between the inoculated calves and the control calf. Endocardial hemorrhages and large soft black-red spleen were present in the 2 calves given the greatest numbers of leptospires. Histopathologically, kidney of all infected calves had multiple small foci of lymphoid cells, chiefly pasmacytes, which were present in periglomerular and interstitial areas.
这是一份关于用问号钩端螺旋体斯瓦吉扎克血清型对牛进行实验性感染的报告。对三头4周龄的荷斯坦-弗里生小母牛进行静脉接种后，主要临床特征为发热、倦怠、厌食、虚弱和腹泻。接种后的前5至8天，从血液中分离出斯瓦吉扎克。在肾脏中发现了钩端螺旋体，但在肝脏、脾脏、大脑或尿液中未发现。3头小牛中有2头产生了同源凝集素，血清最高效价分别为1:80和1:160。产生斯瓦吉扎克凝集素的2头小牛的血清与沃尔夫和哈德乔抗原显示出交叉反应。接种小牛与对照小牛之间的血浆和尿液成分没有显著差异。接种钩端螺旋体数量最多的2头小牛出现了心内膜出血和大的柔软黑红色脾脏。组织病理学上，所有感染小牛的肾脏都有多个小的淋巴细胞灶，主要是浆细胞，存在于肾小球周围和间质区域。
