Merté H J, Stryz J R, Mertz M
Klin Monbl Augenheilkd. 1984 Mar;184(3):227-32.
In results of studies published hitherto it has been found that Pindolol eye drops 1%, a nonselective beta-blocking agent with intrinsic sympathomimetic activity have little or no effect on the bronchopulmonary system. Therefore, a long-term study of the pressure-lowering and other effects of this drug seems in open-angle glaucoma appeared desirable. In a multicenter double-blind trial 41 patients were treated with Pindolol eye drops 1% and 40 with Timolol eye drops 0,5%. A comparison of the two groups showed that their effect in IOP was almost identical. The other parameters of the examination revealed no significant differences between the two groups. - Five patients in the Pindolol group had to discontinue the study due to allergic reactions of the lids and/or conjunctiva .
在迄今发表的研究结果中发现,1%的吲哚洛尔滴眼液,一种具有内在拟交感活性的非选择性β受体阻滞剂,对支气管肺系统几乎没有影响。因此,对该药物在开角型青光眼中的降压及其他作用进行长期研究似乎是可取的。在一项多中心双盲试验中,41例患者使用1%的吲哚洛尔滴眼液治疗,40例患者使用0.5%的噻吗洛尔滴眼液治疗。两组比较显示,它们在降低眼压方面的效果几乎相同。检查的其他参数显示两组之间没有显著差异。——吲哚洛尔组有5例患者因眼睑和/或结膜过敏反应而不得不停止研究。