Reyes H, Gonzalez M C, Ribalta J, Aburto H, Matus C, Schramm G, Katz R, Medina E
Ann Intern Med. 1978 Apr;88(4):487-93. doi: 10.7326/0003-4819-88-4-487.
The prevalence of intrahepatic cholestasis of pregnancy was studied immediately postpartum in 869 women from three distant Chilean cities differing in climate and food supply. Cholestatic jaundice of pregnancy was detected in 2.4% and pruritus gravidarum in 13.2%, without significant differences between the three cities. Every woman was then ethnically classified as predominantly Caucasoid, Araucanian Indian, or Aimara Indian. A significantly higher prevalence of cholestatic jaundice of pregnancy (5.5%) and pruritus gravidarum (22.1%) was found in Araucanians than in Caucasoids (2.5% and 12.6% respectively) or in the Aimaras (0 and 11.8% respectively). The prevalence of intrahepatic cholestasis of pregnancy in Araucanians increased directly with the degree of "ethnic purity." Recurrence of the disease in multiparous women was also greater in Araucanians (13.8%) than in Caucasoids (5.5%) or in the Aimaras (3.9%). We propose that an ethnic predisposition to develop intrahepatic cholestasis of pregnancy is present in Araucanian women and that the high prevalence of the disease in Chile is mainly influenced by ethnic admixture with this South American Indian (ethnic) group.
对来自智利三个气候和食物供应不同的偏远城市的869名女性在产后立即进行了妊娠肝内胆汁淤积症患病率的研究。妊娠胆汁淤积性黄疸的检出率为2.4%，妊娠瘙痒症的检出率为13.2%，三个城市之间无显著差异。然后，根据种族将每位女性主要分为白种人、阿劳坎印第安人或艾马拉印第安人。发现阿劳坎印第安人妊娠胆汁淤积性黄疸（5.5%）和妊娠瘙痒症（22.1%）的患病率显著高于白种人（分别为2.5%和12.6%）或艾马拉人（分别为0和11.8%）。阿劳坎印第安人妊娠肝内胆汁淤积症的患病率随“种族纯度”程度直接增加。多产妇女中该病的复发率在阿劳坎印第安人（13.8%）中也高于白种人（5.5%）或艾马拉人（3.9%）。我们提出，阿劳坎印第安女性存在发生妊娠肝内胆汁淤积症的种族易感性，且智利该病的高患病率主要受与这个南美印第安（种族）群体的种族混合影响。
