Lepistö P, Lahti R
Ann Chir Gynaecol. 1978;67(1):17-21.
Lipids in the pulmonary circulation were determined biochemically and histologically in seven patients (group A) who died following multiple blunt trauma and in five patients (group B) who died of some other traumatic or nontraumatic cause. Autopsy was performed on average 4.5 hours after death. Blood samples were collected from the right ventricle (RV) and the left atrium (LA). The vasculature of the left lung was perfused in a retrograde direction. The inferior lobe of the right non-perfused lung was examined histologically. Intravascular pulmonary fat was observed in 4/6 cases in group A and in 1/5 cases in group B. No intravascular fat was observed in the tissue samples of brain, liver or kidney. The concentration of free fatty acids (FFA) in blood from RV was higher than in blood from LA both in group A (P is less than 0.01) and in group B (P is less than 0.05). The considerable difference in concentrations of FFA between RV and LA and the low concentration of FFA in the lung perfusate may be due to some kind of "fixation" of FFA in the lung tissue, possibly connected with the aetiological factors of the fat embolism syndrome (FES).
对7例因多处钝性创伤死亡的患者（A组）和5例因其他创伤性或非创伤性原因死亡的患者（B组）的肺循环脂质进行了生化和组织学测定。平均在死亡后4.5小时进行尸检。从右心室（RV）和左心房（LA）采集血样。左肺血管进行逆行灌注。对未灌注的右肺下叶进行组织学检查。A组4/6例和B组1/5例观察到血管内肺脂肪。在脑、肝或肾的组织样本中未观察到血管内脂肪。A组（P＜0.01）和B组（P＜0.05）中，RV血中游离脂肪酸（FFA）浓度均高于LA血中FFA浓度。RV和LA之间FFA浓度的显著差异以及肺灌注液中FFA的低浓度可能是由于FFA在肺组织中的某种“固定”，可能与脂肪栓塞综合征（FES）的病因学因素有关。
