Willems J G, Alva-Willems J M
Acta Cytol. 1984 May-Jun;28(3):243-9.
The cytohistologic correlation is reported for 112 of the 128 consecutive sterotactic aspiration biopsies performed on patients with clinical and neuroradiologic evidence of brain tumors investigated at the Neurosurgery Department, Karolinska Hospital, from 1976 to 1979. The cytodiagnostic accuracy of benign and malignant tumors was 87% when adequate cell material was obtained. In 17 benign tumors of the sellar region, the diagnostic rate was 88%; cytologic examination independent of histologic biopsy is feasible in this area. The cytodiagnostic accuracy for 95 malignant central nervous system (CNS) tumors was 87% after adjusting for the appreciable sampling error inherent in the use of a stereotactic procedure during the early phase of the study. Two histopathologically proven infectious lesions were reported cytologically as benign. The main microscopic problems were the recognition of highly differentiated astroglial neoplasms and the differential diagnosis between poorly differentiated brain neoplasms and metastases to the CNS. Cytodiagnostic accuracy of CNS tumors can be increased by technical improvements in the stereotactic device, diagnostic experience and immunochemical staining.
本文报告了1976年至1979年期间在卡罗林斯卡医院神经外科对有脑肿瘤临床和神经放射学证据的患者进行的128例连续立体定向穿刺活检中的112例的细胞组织学相关性。当获得足够的细胞材料时，良性和恶性肿瘤的细胞诊断准确率为87%。在17例鞍区良性肿瘤中，诊断率为88%；在该区域，独立于组织学活检的细胞学检查是可行的。在研究早期，由于立体定向操作存在明显的抽样误差，对95例恶性中枢神经系统（CNS）肿瘤进行调整后，细胞诊断准确率为87%。有2例经组织病理学证实的感染性病变在细胞学上报告为良性。主要的微观问题是高分化星形胶质细胞瘤的识别以及低分化脑肿瘤与CNS转移瘤之间的鉴别诊断。通过立体定向设备的技术改进、诊断经验和免疫化学染色，可以提高CNS肿瘤的细胞诊断准确率。
