Imbs J L, Schmidt M, Giesen E M, Schwartz J
Am J Med. 1984 May 31;76(5B):53-7. doi: 10.1016/0002-9343(84)90884-2.
The inhibition of the renin-angiotensin system by captopril was used in pentobarbital-anesthetized dogs to confirm that the vasoconstrictive action of endorenally synthesized angiotensin II predominates on the efferent glomerular arteriole. Ozolinone is a loop diuretic with two isomers. Only (-)- ozolinone is diuretic, whereas both isomers have a renal vasodilatory effect which predominates on the efferent glomerular arteriole. Only the diuretic isomer increases renin release. The renin hypersecretion is simultaneous with recovery from the initial fall in filtration fraction, because of postglomerular vasodilatation. This recovery does not occur with (+)- ozolinone and is inhibited by pretreatment with captopril. This confirms that vasoconstrictive action of angiotensin II predominates on the efferent glomerular arteriole. Such a vasoconstrictive effect might affect blood flow in the vasa recta, which arise from the efferent arterioles of juxtamedullary glomeruli. This action might enable the renin-angiotensin system to participate in the control of renal medullary blood flow and urinary concentration.
在戊巴比妥麻醉的犬中使用卡托普利抑制肾素-血管紧张素系统，以证实肾内合成的血管紧张素II的血管收缩作用在肾小球出球小动脉上占主导地位。奥唑啉酮是一种具有两种异构体的袢利尿剂。只有（-）-奥唑啉酮具有利尿作用，而两种异构体都具有肾血管舒张作用，且在肾小球出球小动脉上占主导地位。只有利尿异构体可增加肾素释放。由于球后血管舒张，肾素分泌过多与滤过分数最初下降后的恢复同时发生。（+）-奥唑啉酮不会出现这种恢复，且卡托普利预处理可抑制这种恢复。这证实了血管紧张素II的血管收缩作用在肾小球出球小动脉上占主导地位。这种血管收缩作用可能会影响直小血管的血流，直小血管由近髓肾小球的出球小动脉发出。这种作用可能使肾素-血管紧张素系统参与肾髓质血流和尿液浓缩的控制。
