Najemnik C, Kritz H, Irsigler K, Laube H, Knick B, Klimm H D, Wahl P, Vollmar J, Brauning C
Diabetes Care. 1984 May-Jun;7(3):215-20. doi: 10.2337/diacare.7.3.215.
The effect of guar mini-tablets (5 g t.i.d.) on carbohydrate and lipid metabolism of outpatients with overt diabetes mellitus with glycosuria (is greater than 5 g/24 h) was determined in an open-controlled, randomized, multicenter, crossover study. A 4-wk pretreatment period was followed by a 6-wk treatment period. The treatment period consisted of a 2-wk guar period (treatment period II), which was followed by the wash-out period. The other half of the patients received treatment in the reverse order. Out of 93 patient records, 79 (41 sulfonylurea [SU] and 38 insulin-treated) were suitable for statistical analysis. No relevant weight-reducing effect of guar could be found in both 2-wk treatment periods. At the end of treatment period II, the lowering of the 1-h postprandial values of blood glucose (SU 12%, insulin 10%), cholesterol (SU and insulin 25%) was significant after 2-wk of guar treatment compared with the wash-out period. No clinically relevant changes in the safety laboratory parameters were observed during guar treatment. Side effects were observed in 40 of the 93 patients included in the trial. Treatment had to be discontinued in 11% of the patients due to gastrointestinal side effects. On the basis of our results,guar treatment in combination with sulfonylurea and insulin can be recommended for the improvement of carbohydrate and lipid metabolism.
在一项开放对照、随机、多中心、交叉研究中，测定了瓜尔豆微型片（每日3次，每次5克）对显性糖尿病伴糖尿（尿糖大于5克/24小时）门诊患者碳水化合物和脂质代谢的影响。在4周的预处理期之后是6周的治疗期。治疗期包括一个2周的瓜尔豆治疗期（治疗期II），之后是洗脱期。另一半患者按相反顺序接受治疗。在93份患者记录中，79份（41份接受磺脲类药物[SU]治疗，38份接受胰岛素治疗）适合进行统计分析。在两个2周治疗期内均未发现瓜尔豆有明显的减重作用。在治疗期II结束时，与洗脱期相比，瓜尔豆治疗2周后，餐后1小时血糖值（磺脲类药物治疗组降低12%，胰岛素治疗组降低10%）、胆固醇（磺脲类药物治疗组和胰岛素治疗组均降低25%）的降低具有显著性。在瓜尔豆治疗期间，未观察到安全实验室参数有临床相关变化。在纳入试验的93例患者中，有40例出现了副作用。11%的患者因胃肠道副作用而不得不停止治疗。根据我们的研究结果，瓜尔豆与磺脲类药物和胰岛素联合治疗可推荐用于改善碳水化合物和脂质代谢。
