Niemi M K, Keinänen-Kiukaanniemi S M, Salmela P I
Department of Public Health Science, University of Oulu, Finland.
Eur J Clin Pharmacol. 1988;34(4):427-9. doi: 10.1007/BF00542449.
The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting BG was found after 6 weeks treatment with GG, but the initial level was regained after further 6 weeks, at the end of the treatment period. No statistically significant change in fasting BG was observed with MC. Serum cholesterol was lowered by 10% during GG treatment. Microcrystalline cellulose had no effect on serum lipids. The results suggest, that during 12 weeks supplementation with guar gum, the improvement in glycemic control was not sustained, but that it might reduce the risk of macrovascular disease in diabetic patients.
在一项针对18名控制不佳的2型糖尿病患者的双盲交叉试验中，比较了瓜尔胶（GG）和微晶纤维素（MC）对代谢控制和血脂的影响。试验有两个为期12周的治疗期，中间间隔4周的洗脱期。用GG治疗6周后，空腹血糖显著降低，但在治疗期结束时，再经过6周，血糖恢复到初始水平。使用MC时，空腹血糖未观察到有统计学意义的变化。在GG治疗期间，血清胆固醇降低了10%。微晶纤维素对血脂没有影响。结果表明，在补充瓜尔胶的12周期间，血糖控制的改善未能持续，但它可能会降低糖尿病患者发生大血管疾病的风险。
