González-Garza M T, Fernandez-Quintero P, Arellano-Blanco J, Gómez-Estrada H
Arch Invest Med (Mex). 1978;9(1):33-50.
BALB/C mice were treated with epsilon aminocaproic acid (EACA), 0.1 to 3.2 mg/g body weight, subcutaneously every 24 hours for six days, starting on the second day after intraperitoneal transplantation of L5178Y lymphoma. Complete involution was observed in 20 to 90 per cent of the ascitic tumor and in 50 per cent of the solid tumor 72 hours after EACA was discontinued, tumoral involution and dosage were directly proportional. One hundred per cent of the non treated controls died 10 +/- 0.6 days after intraperitoneal lymphoma transplantation. During tumor involution malignant cells underwent autolysis and were attacked or phagocytized by activated macrophages. Since EACA is a proteolytic enzyme inhibitor, inhibition during treatment and activation of these enzymes after EACA was discontinued could have been the cause of autolysis of the L5178Y lymphoma cells.
在L5178Y淋巴瘤腹腔移植后的第二天开始，给BALB/C小鼠皮下注射ε-氨基己酸（EACA），剂量为0.1至3.2毫克/克体重，每24小时一次，共六天。在停用EACA 72小时后，观察到20%至90%的腹水瘤和50%的实体瘤完全消退，肿瘤消退与剂量成正比。未经治疗的对照组在腹腔内移植淋巴瘤后10±0.6天全部死亡。在肿瘤消退过程中，恶性细胞发生自溶，并受到活化巨噬细胞的攻击或吞噬。由于EACA是一种蛋白水解酶抑制剂，治疗期间的抑制作用以及停用EACA后这些酶的激活可能是L5178Y淋巴瘤细胞自溶的原因。
