Donoso A O, Banzan A M
Acta Endocrinol (Copenh). 1984 Jul;106(3):298-304. doi: 10.1530/acta.0.1060298.
The effects of increasing brain GABA levels by administration of aminooxyacetic acid (AOAA), a GABA-transaminase inhibitor, on tonic and induced LH release were evaluated in ovariectomized rats. Pulsatile LH release was clearly inhibited by AOAA. Mean plasma LH levels fell, the frequently of pulses decreased, and the intervals between pulses increased. An absence of LH pulses was seen in some animals. Administration of the GABA antagonist, bicuculline, prevented these modifications. In addition, it enhanced mean plasma LH levels. AOAA blunted the rise of plasma LH levels produced by either oestradiol or progesterone in oestradiol-primed ovariectomized rats. In contrast, the AOAA treatment apparently facilitated the inhibitory feedback of oestradiol on LH release. The acute release of LH produced by LRH injection was not altered by AOAA. The results support the view that brain GABA exerts an inhibitory action on LH release in the rat.
在去卵巢大鼠中评估了通过给予γ-氨基丁酸转氨酶抑制剂氨氧乙酸（AOAA）来提高脑内γ-氨基丁酸（GABA）水平对促黄体生成素（LH）的基础释放和诱导释放的影响。AOAA明显抑制了LH的脉冲式释放。血浆LH的平均水平下降，脉冲频率降低，脉冲间隔增加。在一些动物中观察到LH脉冲消失。给予GABA拮抗剂荷包牡丹碱可阻止这些变化。此外，它还提高了血浆LH的平均水平。AOAA减弱了雌二醇预处理的去卵巢大鼠中由雌二醇或孕酮引起的血浆LH水平的升高。相反，AOAA处理明显促进了雌二醇对LH释放的负反馈抑制。注射促性腺激素释放激素（LRH）引起的LH急性释放不受AOAA影响。这些结果支持这样一种观点，即脑内GABA对大鼠LH释放具有抑制作用。
