Regoeczi E, Chindemi P A, Debanne M T
Alcohol Clin Exp Res. 1984 May-Jun;8(3):287-92. doi: 10.1111/j.1530-0277.1984.tb05513.x.
The hepatic uptake of 59Fe from diferric rat and rabbit asialotransferrins and from human transferrin lacking two sialyl residues was investigated in rats in experiments lasting for 1 hr. The 59Fe attached to either of these preparations disappeared from the plasma more rapidly than the 59Fe introduced with the unmodified respective parent proteins. Most of the 59Fe activity that had disappeared from the circulation could be recovered with the liver. Studies with double-labeled (125I, 59Fe) preparations showed that the enhanced 59Fe clearance was not associated with increased catabolism of the modified transferrins. Prolonged, heavy alcohol consumption, as shown by others, results in the appearance of sialic acid-deficient transferrin (two residues missing) in human serum. We suggest that the increased capacity of transferrin deficient in sialic acid to selectively deposit iron in the hepatocyte may be of significance for the development of the hepatic siderosis observed in alcoholism.
在持续1小时的实验中，研究了大鼠对来自双铁大鼠和兔去唾液酸转铁蛋白以及来自缺少两个唾液酸残基的人转铁蛋白的59Fe的肝脏摄取情况。与这些制剂中的任何一种结合的59Fe从血浆中消失的速度比与未修饰的相应亲本蛋白一起引入的59Fe更快。从循环中消失的大部分59Fe活性可以在肝脏中回收。对双标记（125I，59Fe）制剂的研究表明，增强的59Fe清除率与修饰转铁蛋白的分解代谢增加无关。如其他人所示，长期大量饮酒会导致人血清中出现缺乏唾液酸的转铁蛋白（缺少两个残基）。我们认为，缺乏唾液酸的转铁蛋白选择性地在肝细胞中沉积铁的能力增加可能对酒精中毒中观察到的肝铁沉积症的发展具有重要意义。
