吲哚美辛和舒林酸对高血压患者阿替洛尔某些药理作用的影响。
The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients.
作者信息
Salvetti A, Pedrinelli R, Alberici P, Magagna A, Abdel-Haq B
出版信息
Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):108S-111S. doi: 10.1111/j.1365-2125.1984.tb02442.x.
Abstract
Indomethacin and sulindac were used as tools to study the role of renal and/or systemic prostaglandins in the pharmacological response to atenolol. Patients receiving chronic treatment with atenolol 100 mg received indomethacin 50 mg twice daily or sulindac 200 mg twice daily in a randomised crossover trial. Indomethacin significantly reduced the antihypertensive action of atenolol while sulindac had no effect. The role that systemic and/or renal prostaglandins may play in the antihypertensive action of atenolol is discussed with reference to renal PGI2 production and inhibition of platelet cyclo-oxygenase.
摘要
吲哚美辛和舒林酸被用作研究肾脏和/或全身前列腺素在阿替洛尔药理反应中作用的工具。在一项随机交叉试验中，接受100毫克阿替洛尔长期治疗的患者，每天两次服用50毫克吲哚美辛或每天两次服用200毫克舒林酸。吲哚美辛显著降低了阿替洛尔的降压作用，而舒林酸没有效果。参照肾脏前列环素I2的产生和血小板环氧化酶的抑制作用，讨论了全身和/或肾脏前列腺素在阿替洛尔降压作用中可能发挥的作用。
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