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The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients.吲哚美辛和舒林酸对高血压患者阿替洛尔某些药理作用的影响。
Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):108S-111S. doi: 10.1111/j.1365-2125.1984.tb02442.x.
2
Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects.
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3
Sulindac does not spare renal prostaglandins.
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4
The influence of selective and nonselective prostaglandin inhibition on renin.选择性和非选择性前列腺素抑制对肾素的影响。
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Sulindac is not renal sparing in man.舒林酸对人体并无肾脏保护作用。
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Inhibition of prostaglandin synthesis by indomethacin interacts with the antihypertensive effect of atenolol.吲哚美辛对前列腺素合成的抑制作用与阿替洛尔的降压作用相互影响。
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Effects of indomethacin and sulindac on hydrochlorothiazide kinetics.
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The effects of sulindac and indomethacin on the anti-hypertensive and diuretic action of hydrochlorothiazide in patients with mild to moderate essential hypertension.舒林酸和吲哚美辛对轻度至中度原发性高血压患者氢氯噻嗪的降压和利尿作用的影响。
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[Clinical relevance of drug interactions between nonsteroidal antiinflammatory drugs (NSAIDs) and antihypertensives].[非甾体抗炎药（NSAIDs）与抗高血压药物之间药物相互作用的临床相关性]
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beta-blockers. Drug interactions of clinical significance.β受体阻滞剂。具有临床意义的药物相互作用。
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Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril.吲哚美辛和卡托普利预处理后皮内注射缓激肽引起的皮肤血流变化及风团
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本文引用的文献

1
Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function.血清血栓素B2的放射免疫测定：一种评估药物对血小板功能影响的简单方法。
Adv Prostaglandin Thromboxane Res. 1980;6:187-91.
2
Interaction between oxprenolol and indomethacin on blood pressure in essential hypertensive patients.心得平与消炎痛对原发性高血压患者血压的相互作用。
Eur J Clin Pharmacol. 1982;22(3):197-201. doi: 10.1007/BF00545214.
3
Evidence for a direct stimulatory effect of prostacyclin on renin release in man.前列环素对人体肾素释放有直接刺激作用的证据。
J Clin Invest. 1982 Jan;69(1):231-9. doi: 10.1172/jci110435.
4
Control of the enzyme systems in plasma renin activity measurement by angiotensin I radioimmunoassay.通过血管紧张素I放射免疫测定法控制血浆肾素活性测量中的酶系统。
J Nucl Biol Med. 1973 Oct-Dec;17(4):187-95.
5
Modification by indomethacin of the blood pressure lowering effect of pindolol and propranolol in conscious rabbits.吲哚美辛对清醒家兔中吲哚洛尔和普萘洛尔降压作用的影响
Eur J Pharmacol. 1977 Jun 15;43(4):377-81. doi: 10.1016/0014-2999(77)90044-9.
6
Effects of indomethacin alone and during diuretic or beta-adrenoreceptor-blockade therapy on blood pressure and the renin system in essential hypertension.
Clin Sci Mol Med Suppl. 1978 Dec;4:203s-205s. doi: 10.1042/cs055203s.

吲哚美辛和舒林酸对高血压患者阿替洛尔某些药理作用的影响。

The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients.

作者信息

Salvetti A, Pedrinelli R, Alberici P, Magagna A, Abdel-Haq B

出版信息

Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):108S-111S. doi: 10.1111/j.1365-2125.1984.tb02442.x.

DOI:10.1111/j.1365-2125.1984.tb02442.x
PMID:6378233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463273/
Abstract

Indomethacin and sulindac were used as tools to study the role of renal and/or systemic prostaglandins in the pharmacological response to atenolol. Patients receiving chronic treatment with atenolol 100 mg received indomethacin 50 mg twice daily or sulindac 200 mg twice daily in a randomised crossover trial. Indomethacin significantly reduced the antihypertensive action of atenolol while sulindac had no effect. The role that systemic and/or renal prostaglandins may play in the antihypertensive action of atenolol is discussed with reference to renal PGI2 production and inhibition of platelet cyclo-oxygenase.

摘要

吲哚美辛和舒林酸被用作研究肾脏和/或全身前列腺素在阿替洛尔药理反应中作用的工具。在一项随机交叉试验中，接受100毫克阿替洛尔长期治疗的患者，每天两次服用50毫克吲哚美辛或每天两次服用200毫克舒林酸。吲哚美辛显著降低了阿替洛尔的降压作用，而舒林酸没有效果。参照肾脏前列环素I2的产生和血小板环氧化酶的抑制作用，讨论了全身和/或肾脏前列腺素在阿替洛尔降压作用中可能发挥的作用。