Colonic and gastric mucus-associated antigens: a comparative immunohistological study in precancerous and cancerous rat intestinal mucosa.

Gastric M1 antigens were previously shown to be oncofetal markers for the colon in man and in the rat. They were observed very early during carcinogenesis in goblet cells of precancerous colonic mucosa; using an immunohistological method, we found that M1 were produced in 68% (41/60) of colonic adenocarcinomas and in 33% (21/63) of duodenal adenocarcinomas. M3C antigen has been described as being associated with human colonic mucus; in the rat it is restricted to the proximal colon. We found that M3C was produced in 91% (55/60) of colonic adenocarcinomas and in 15% (8/53) of duodenal adenocarcinomas. Before tumor appearance, M3C was sometimes expressed by goblet cells of the distal colon. We could not find it during fetal life. We have concluded that mucus-associated antigens can characterize modifications in cell differentiation in rat colonic carcinomas.