Troxel T R, Kesler D J
J Anim Sci. 1984 Jul;59(1):177-81. doi: 10.2527/jas1984.591177x.
Fourteen anovulatory postpartum (38.0 +/- 1.9 d) beef cows that ovulated after an injection of 250 micrograms gonadotropin releasing hormone (GnRH) in saline were used to examine the influence of indomethacin on luteal function. Beginning the d after GnRH, 6 cows were given intrauterine infusions of indomethacin for 14 d and the other eight cows received vehicle. After GnRH treatment, concentrations of progesterone in serum were elevated longer (P less than .01) for indometacin-treated cows than for vehicle-treated cows. At the same time prostaglandin metabolite (PGFM) concentrations were lower (P less than .01) in indomethacin-treated cows than in vehicle-treated cows. In summary, indomethacin suppressed PGFM concentrations and enhanced function of corpora lutea induced in postpartum suckled beef cows.
选取14头产后无排卵（产后38.0±1.9天）的肉牛母牛，在注射250微克促性腺激素释放激素（GnRH）溶于生理盐水后排卵，用于研究吲哚美辛对黄体功能的影响。从注射GnRH后的第一天开始，6头母牛进行吲哚美辛宫内灌注，持续14天，另外8头母牛接受赋形剂。GnRH治疗后，吲哚美辛治疗组母牛血清中孕酮浓度升高的时间比赋形剂治疗组母牛更长（P<0.01）。同时，吲哚美辛治疗组母牛的前列腺素代谢物（PGFM）浓度低于赋形剂治疗组母牛（P<0.01）。总之，吲哚美辛抑制了PGFM浓度，并增强了产后哺乳肉牛母牛诱导黄体的功能。
