不同前列腺素类似物对犬胃酸分泌及胃黏膜血流的影响：对刺激状态和静息状态胃黏膜的作用
Effect of different prostaglandin analogues on gastric acid secretion and mucosal blood flow in the dog: action on stimulated and resting mucosa.
作者信息
Bálint G A, Sági I, Döbrönte Z, Varró V
出版信息
Acta Med Hung. 1984;41(2-3):149-55.
PMID:6379594
Abstract
The effect of PG-E2, 16-16-DMPGE2, PG-F2 alpha and PG-I2 was investigated on histamine stimulated and resting canine gastric mucosa. PG-F2 alpha had no effect on mucosal circulation or acid secretion. PG-E2 and 16-16-DMPGE2 showed an increasing effect on blood flow of the resting mucosa. PG-E2, 16-16-DMPGE2 and PG-I2 decreased of acid secretion; the effect seemed to be due to a direct action on the parietal cells.
摘要
研究了前列腺素E2、16-16-二甲基前列腺素E2、前列腺素F2α和前列腺素I2对组胺刺激的和静息的犬胃黏膜的影响。前列腺素F2α对黏膜循环或酸分泌无影响。前列腺素E2和16-16-二甲基前列腺素E2对静息黏膜的血流有增加作用。前列腺素E2、16-16-二甲基前列腺素E2和前列腺素I2可减少酸分泌；这种作用似乎是由于对壁细胞的直接作用。
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