橙剂成分及相关化学品的致突变性测试。

Mutagenicity testing of agent orange components and related chemicals.

作者信息

Mortelmans K, Haworth S, Speck W, Zeiger E

出版信息

Toxicol Appl Pharmacol. 1984 Aug;75(1):137-46. doi: 10.1016/0041-008x(84)90084-x.

Abstract

Components of the herbicide Agent Orange--2,4-dichlorophenoxyacetic acid (2,4,-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and their esters, and the contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)--and related chemicals were tested for mutagenicity using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537. No mutagenic activity was observed for any of the chemicals tested.

摘要

除草剂橙剂的成分——2,4-二氯苯氧乙酸（2,4-D）、2,4,5-三氯苯氧乙酸（2,4,5-T）及其酯类，以及污染物2,3,7,8-四氯二苯并对二恶英（TCDD）——和相关化学品，使用鼠伤寒沙门氏菌菌株TA98、TA100、TA1535和TA1537进行了致突变性测试。所测试的任何化学品均未观察到致突变活性。