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缺血性损伤后球旁复合体的转归

Fate of the juxtaglomerular complex after ischemic injury.

作者信息

Mujović S

出版信息

Acta Anat (Basel). 1984;118(3):181-6.

PMID:6380189
Abstract

The juxtaglomerular (JG) complex was studied at different times after 90 min of warm kidney ischemia: 2 h, 24 h, 3 days, 10 and 30 days following the ischemia. The ischemic injury was performed on the left kidney, under two experimental conditions: with and without previous nephrectomy of the contralateral nonischemic kidney. The activity of the JG complex was evaluated by assessing the JG index and by determination of plasma renin activity. Results show that, under given experimental conditions, fate of the particular JG complex depends on the fate of its own nephron. In the presence of the contralateral intact kidney most nephrons of the ischemic kidney underwent gradual degeneration and their JG complexes degenerated too. When ischemic kidney was the sole kidney, the majority of nephron units regenerated and their JG complexes recovered both morphologically and functionally.

摘要

在肾脏热缺血90分钟后的不同时间点(缺血后2小时、24小时、3天、10天和30天)对肾小球旁(JG)复合体进行了研究。在两种实验条件下对左肾进行缺血损伤:对侧非缺血肾先前已切除或未切除。通过评估JG指数和测定血浆肾素活性来评估JG复合体的活性。结果表明,在给定的实验条件下,特定JG复合体的命运取决于其自身肾单位的命运。在对侧肾脏完整的情况下,缺血肾脏的大多数肾单位逐渐退化,其JG复合体也发生退化。当缺血肾是唯一的肾脏时,大多数肾单位会再生,其JG复合体在形态和功能上都能恢复。

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