Decreased permeability of glycerol in an ergosterol-less mutant of Candida albicans.

In a comparative study, an ergosterol-less nystatin-resistant mutant of Candida albicans and its ergosterol-producing nystatin-sensitive parental strain were investigated. The sterol mutant showed a more significantly decreased growth yield, respiration and glycerol-uptake activity than the parental strain as the consequence of its altered plasma membrane lipid composition.