Hopff W H, Riggio G, Waser P G
Acta Pharmacol Toxicol (Copenh). 1984 Jul;55(1):1-5. doi: 10.1111/j.1600-0773.1984.tb01954.x.
Contrary to the large number of publications dealing with treatment of organophosphate poisoning in a variety of animal species, there is no logic reason in the preference of one species, for this purpose. Guinea pigs were reported to respond better to treatment by oximes, than mice and rats. However, in the analysis of data on the effect of obidoxim and atropine or benactyzine on sarin poisoning it is demonstrated, that guinea pigs do not respond differently from mice and rats. Subcutaneous LD50's of sarin in mice ranged from 0.06 to 0.207 mg/kg, and those of guinea pigs from 0.04 to 0.112 mg/kg. The difference in the LD50's may be related to the different susceptibility of various animal species. The importance of "in vivo" dosage, mode of application, kinetics of antagonists, in correlation to the ability to reactivate "in vitro" is discussed.
与大量关于多种动物物种有机磷中毒治疗的出版物相反，就这一目的而言，没有逻辑上的理由偏好某一物种。据报道，豚鼠对肟类药物治疗的反应比小鼠和大鼠更好。然而，在分析双复磷和阿托品或苯那辛对沙林中毒影响的数据时发现，豚鼠与小鼠和大鼠的反应并无差异。沙林对小鼠的皮下半数致死量为0.06至0.207毫克/千克，对豚鼠为0.04至0.112毫克/千克。半数致死量的差异可能与不同动物物种的不同易感性有关。讨论了“体内”剂量、给药方式、拮抗剂动力学与“体外”重新激活能力之间的相关性。
