Nazar R N
Can J Biochem Cell Biol. 1984 Jun;62(6):311-20. doi: 10.1139/o84-044.
A striking difference between the cytoplasmic ribosomes of eukaryotes and prokaryotes is the presence (in eukaryotes) of one additional RNA component, the 5.8S rRNA. This RNA, which is hydrogen bonded to the cognate high molecular weight RNA of the large subunit, is about 160 nucleotides in length, and is cotranscribed with the high molecular weight rRNA as part of a much larger precursor molecule, the nucleolar 36S-45S rRNA. Because of its relatively small size the 5.8S RNA is considered a good model for studies on rRNA structure, synthesis, maturation, ribosomal integration, function, and even evolution. Over the last decade numerous studies have examined these questions with many interesting results, including the probability that this RNA sequence may actually be present in all ribosomes, although not necessarily as a separate RNA component. Their findings are summarized in this review.
真核生物和原核生物的细胞质核糖体之间一个显著的差异是（真核生物中）存在一种额外的RNA组分，即5.8S rRNA。这种RNA通过氢键与大亚基的同源高分子量RNA结合，长度约为160个核苷酸，并且与高分子量rRNA一起作为一个大得多的前体分子（核仁36S - 45S rRNA）的一部分进行共转录。由于其相对较小的尺寸，5.8S RNA被认为是研究rRNA结构、合成、成熟、核糖体整合、功能乃至进化的一个良好模型。在过去十年中，众多研究探讨了这些问题并取得了许多有趣的结果，包括这种RNA序列实际上可能存在于所有核糖体中，尽管不一定作为一个单独的RNA组分。本文综述总结了他们的研究发现。
