Gehan E A
Cancer. 1984 Sep 15;54(6 Suppl):1204-7. doi: 10.1002/1097-0142(19840915)54:1+<1204::aid-cncr2820541318>3.0.co;2-z.
The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment. Examples are given from clinical studies in Hodgkin's disease, acute leukemia, and breast cancer that may prove useful in planning future clinical studies.
本文综述了临床肿瘤学中剂量（及剂量率）与反应和毒性之间的关系。简要回顾了一些作者在动物和人体系统剂量反应研究中所表达的概念。对放射治疗和各类化疗的剂量率及临床研究策略进行了综述。文中列举了霍奇金淋巴瘤、急性白血病和乳腺癌临床研究的实例，这些实例可能对未来临床研究的规划有所帮助。
