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人类胎儿组织中的铜、锰、锌、镍、镉和铅。

Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissues.

作者信息

Casey C E, Robinson M F

出版信息

Br J Nutr. 1978 May;39(3):639-46. doi: 10.1079/bjn19780079.

DOI:10.1079/bjn19780079
PMID:638131
Abstract
  1. Concentrations of copper, manganese, zinc, nickel, cadmium and lead were measured in samples of liver, kidney, brain, heart, lung, skeletal muscle and vertebral bone from forty foetuses of 23-43 weeks gestation. 2. Cu concentrations in the liver were up to 100 times those in other tissues, but only those in the brain showed a significant increase with gestational age. 3. Mn concentrations were similar in all tissues; the over-all range was 0.35-9.27 microgram/g dry matter (DM). 4. Concentrations of Zn in the liver were much higher than in other tissues and decreased with gestational age, whereas levels in skeletal muscle increased. 5. In all tissues Ni concentrations were within the range 0.04-2.8 microgram/g DM and levels in kidney and muscle decreased significantly with age. 6. Cd was detected in most of the tissue samples and concentrations were within the range 0.01-0.58 microgram/g DM. 7. Concentrations of Pb, where it was detected, varied from 0.1 to 2.4 microgram/g DM in the soft tissues and from 0.4 to 4.3 microgram/g DM in the bone samples.
摘要
  1. 对23至43周妊娠的40例胎儿的肝脏、肾脏、大脑、心脏、肺、骨骼肌和椎骨样本中的铜、锰、锌、镍、镉和铅浓度进行了测量。2. 肝脏中的铜浓度比其他组织高出多达100倍,但只有大脑中的铜浓度随胎龄显著增加。3. 所有组织中的锰浓度相似;总体范围为0.35至9.27微克/克干物质(DM)。4. 肝脏中的锌浓度远高于其他组织,并随胎龄降低,而骨骼肌中的锌水平则升高。5. 所有组织中的镍浓度在0.04至2.8微克/克DM范围内,肾脏和肌肉中的镍水平随年龄显著降低。6. 在大多数组织样本中检测到镉,浓度在0.01至0.58微克/克DM范围内。7. 在软组织中检测到的铅浓度在0.1至2.4微克/克DM之间,在骨样本中为0.4至4.3微克/克DM。

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