Richmond R C
Radiat Res. 1984 Sep;99(3):596-608.
The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.
氧化配位化合物顺二氯二氨铂（II）（顺铂）再次被证明是一种乏氧细胞辐射增敏剂。顺铂诱导辐射增敏的机制很复杂。此处结果表明，顺铂增敏作用部分通过活性自由基起作用，部分通过辐射诱导的活性铂（I）中间体的相互作用起作用，部分通过辐照期间铂（II）与DNA结合的热力学和动力学方面的参与起作用。在同一研究中，首次将反铂的辐射增敏作用与顺铂的增敏浓度进行了比较。两种类似物都是增敏剂，但存在显著差异。此外，发现辐照后的顺铂乏氧溶液比未辐照的溶液毒性更大。
