Eichner E R
Am J Med. 1984 Sep;77(3):513-23. doi: 10.1016/0002-9343(84)90113-x.
"Antiplatelet" drugs and certain life styles seem to have an "antithrombotic" effect that may help protect against stroke and heart attack. This review of the experience with aspirin, dipyridamole, and sulfinpyrazone offers new interpretations of some of the major clinical trials, suggests guidelines for use of antiplatelet drugs, and integrates novel observations on diet and exercise into the "thromboxane-prostacyclin balance" hypothesis. It is argued that the Canadian stroke study showed that aspirin protects men with transient ischemic attacks from coronary death as well as from stroke, that type II errors may have been made in some clinical trials, that aspirin protects women as well as men, that aspirin benefits patients who have had a heart attack, that the effect of aspirin in angina varies with the type of angina, that the dose of aspirin used may not be critical, that guidelines for use of dipyridamole and sulfinpyrazone are still inconclusive, and that exercise and fish oil supplements may be "antithrombotic."
“抗血小板”药物和某些生活方式似乎具有“抗血栓形成”作用，可能有助于预防中风和心脏病发作。这篇对阿司匹林、双嘧达莫和苯磺唑酮使用经验的综述对一些主要临床试验提出了新的解读，给出了抗血小板药物的使用指南，并将关于饮食和运动的新观察结果纳入“血栓素 - 前列环素平衡”假说。有人认为，加拿大中风研究表明阿司匹林可保护短暂性脑缺血发作的男性预防冠状动脉死亡以及中风，一些临床试验可能存在Ⅱ类错误，阿司匹林对女性和男性都有保护作用，阿司匹林对心脏病发作患者有益，阿司匹林在心绞痛中的作用因心绞痛类型而异，所用阿司匹林剂量可能并非关键因素，双嘧达莫和苯磺唑酮的使用指南仍无定论，运动和鱼油补充剂可能具有“抗血栓形成”作用。
