Voorhess M L, MacGillivray M H
J Clin Endocrinol Metab. 1984 Oct;59(4):790-3. doi: 10.1210/jcem-59-4-790.
Norepinephrine (NE) is a neurotransmitter of the sympathetic nervous system which is important in GH secretion. It also is a counterregulatory hormone which is released in response to insulin hypoglycemia. We measured the plasma NE, epinephrine, GH, and cortisol responses to insulin-induced hypoglycemia in 29 short healthy children. The 8 patients (5 males and 3 females) which had isolated GH deficiency had no plasma NE response to insulin hypoglycemia, whereas mean plasma NE increased 2-fold in the 21 GH-sufficient children. Plasma epinephrine concentrations increased in both groups, but were lower in the GH-deficient patients. While these findings do not permit us to determine whether the reduced plasma catecholamine responses to acute hypoglycemia are the cause, the consequence, or unrelated to the GH deficiency, we speculate that there is a relationship between the NE and GH deficiencies.
去甲肾上腺素（NE）是交感神经系统的一种神经递质，对生长激素（GH）分泌很重要。它也是一种反调节激素，在胰岛素低血糖反应时释放。我们测量了29名健康矮小儿童对胰岛素诱导的低血糖反应时血浆中的去甲肾上腺素、肾上腺素、生长激素和皮质醇水平。8例孤立性生长激素缺乏的患者（5例男性，3例女性）对胰岛素低血糖无血浆去甲肾上腺素反应，而21例生长激素充足的儿童血浆去甲肾上腺素平均增加了2倍。两组患者血浆肾上腺素浓度均升高，但生长激素缺乏患者的浓度较低。虽然这些发现不能让我们确定对急性低血糖时血浆儿茶酚胺反应降低是生长激素缺乏的原因、结果还是与之无关，但我们推测去甲肾上腺素缺乏与生长激素缺乏之间存在关联。
