Budinger T F, Lauterbur P C
Science. 1984 Oct 19;226(4672):288-98. doi: 10.1126/science.6385252.
Nuclear magnetic resonance proton imaging provides anatomical definition of normal and abnormal tissues with a contrast and detection sensitivity superior to those of x-ray computed tomography in the human head and pelvis and parts of the cardiovascular and musculoskeletal systems. Recent improvements in technology should lead to advances in diagnostic imaging of the breast and regions of the abdomen. Selected-region nuclear magnetic resonance spectroscopy of protons, carbon-13, and phosphorus-31 has developed into a basic science tool for in vivo studies on man and a unique tool for clinical diagnoses of metabolic disorders. At present, nuclear magnetic resonance is considered safe if access to the magnet environment is controlled. Technological advances employing field strengths over 2 teslas will require biophysical studies of heating and static field effects.
核磁共振质子成像可对正常和异常组织进行解剖学定义，其对比度和检测灵敏度优于X射线计算机断层扫描，适用于人体头部、骨盆以及心血管和肌肉骨骼系统的部分区域。技术上的最新进展应会推动乳腺和腹部区域诊断成像的发展。对质子、碳-13和磷-31进行的选定区域核磁共振波谱分析已发展成为人体体内研究的基础科学工具以及代谢紊乱临床诊断的独特工具。目前，如果对磁体环境的进入加以控制，核磁共振被认为是安全的。采用超过2特斯拉场强的技术进步将需要对加热和静磁场效应进行生物物理学研究。
