通过磷核磁共振波谱法进行的急性肠缺血研究。
Acute intestinal ischemia studies by phosphorus nuclear magnetic resonance spectroscopy.
作者信息
Blum H, Summers J J, Schnall M D, Barlow C, Leigh J S, Chance B, Buzby G P
出版信息
Ann Surg. 1986 Jul;204(1):83-8. doi: 10.1097/00000658-198607000-00012.
Abstract
31P nuclear magnetic resonance (NMR) spectroscopy has been used to follow the metabolism of acutely ischemic rat small intestine and its recovery after reversal of ischemia. Loops of small intestine were subjected to occlusive external pressure for up to 60 minutes, followed by a recovery period. The depletion of PCr and ATP is rapid and complete within 20 minutes. Recovery from ischemia is also rapid but with recovery ATP levels lower than initial values after prolonged ischemic periods. Intestinal shock was avoided. Clinical recovery correlated with shorter ischemic periods. 31P NMR spectroscopy thus appears to be a suitable technique for studying the effects of pharmacological agents and other treatments for amelioration of ischemic effects on the bowel.
摘要
31P核磁共振（NMR）光谱已被用于追踪急性缺血大鼠小肠的代谢及其缺血逆转后的恢复情况。将小肠肠袢施加外部闭塞压力长达60分钟，随后进入恢复期。磷酸肌酸（PCr）和三磷酸腺苷（ATP）在20分钟内迅速且完全耗尽。缺血后的恢复也很快，但在长时间缺血后，恢复的ATP水平低于初始值。避免了肠休克。临床恢复与较短的缺血时间相关。因此，31P NMR光谱似乎是一种适合研究药物和其他治疗方法对改善肠道缺血影响的技术。
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本文引用的文献
1
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J Pathol Bacteriol. 1959 Apr;77(2):505-10. doi: 10.1002/path.1700770222.
2
Localization of metabolites in animals using 31P topical magnetic resonance.使用31P局部磁共振对动物体内代谢物进行定位
Nature. 1980 Oct 23;287(5784):736-8. doi: 10.1038/287736a0.
3
4
Acute mesenteric vascular occlusion: a review of 40 cases.
Int Surg. 1980 May-Jun;65(3):231-4.
5
Phosphorus nuclear magnetic resonance spectroscopy of cardiac and skeletal muscles.心脏和骨骼肌的磷核磁共振波谱分析
Am J Physiol. 1982 May;242(5):H729-44. doi: 10.1152/ajpheart.1982.242.5.H729.
6
Monitoring of cellular metabolism by NMR.通过核磁共振监测细胞代谢。
Biochim Biophys Acta. 1981 Nov 9;639(1):53-76. doi: 10.1016/0304-4173(81)90005-7.
7
NMR studies of tissue metabolism.组织代谢的核磁共振研究。
Annu Rev Biochem. 1981;50:69-83. doi: 10.1146/annurev.bi.50.070181.000441.
8
Response of the intestinal mucosa to ischaemia.肠黏膜对缺血的反应。
Gut. 1981 Jun;22(6):512-27. doi: 10.1136/gut.22.6.512.
9
Vasodilation of the normal and ischemic canine mesenteric circulation.
Gastroenterology. 1981 Jun;80(6):1542-9.
10
Carcinoma of the pancreas: results of irradiation for unresectable lesions.胰腺癌：不可切除性病变的放射治疗结果
Int J Radiat Oncol Biol Phys. 1980 Feb;6(2):209-12. doi: 10.1016/0360-3016(80)90039-5.
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