前瞻性HLA - A和 - B配型对288例单纯疱疹性角膜炎穿透性角膜移植术的影响。

The effect of prospective HLA-A and -B matching in 288 penetrating keratoplasties for herpes simplex keratitis.

作者信息

Völker-Dieben H J, Kok-van Alphen C C, D'Amaro J, de Lange P

出版信息

Acta Ophthalmol (Copenh). 1984 Aug;62(4):513-23. doi: 10.1111/j.1755-3768.1984.tb03962.x.

DOI:10.1111/j.1755-3768.1984.tb03962.x

Abstract

A retrospective review of 288 penetrating keratoplasties (PKP) for herpes simplex keratitis demonstrated a 60.4% survival rate of clear grafts at 3 years. A highly significant difference in corneal graft survival in severely vascularized corneas (57.1% at 3 years) versus non- or slightly vascularized corneas (82.8% at 3 years) was observed (P = 0.009). Prospectively HLA-A and -B matched grafts in vascularized corneas revealed a significantly improved graft survival when compared to unmatched grafts (P = 0.035). Corneal graft survival in eyes grafted 'à chaud' was not significantly below the graft survival of vascularized corneas with a clinically non-active herpetic corneal disease. Recurrence of herpes simplex in the graft was observed in an earlier postoperative period in HLA-A and -B matched grafts (P = 0.0004).

摘要

一项针对288例单纯疱疹性角膜炎穿透性角膜移植术（PKP）的回顾性研究表明，3年后透明植片的存活率为60.4%。观察到严重血管化角膜的角膜移植存活率（3年后为57.1%）与无血管或轻度血管化角膜（3年后为82.8%）存在高度显著差异（P = 0.009）。前瞻性研究显示，在血管化角膜中，HLA - A和 - B配型的移植物与未配型的移植物相比，移植物存活率显著提高（P = 0.035）。“热植”眼的角膜移植存活率并不显著低于患有临床非活动性单纯疱疹性角膜病的血管化角膜的移植存活率。在HLA - A和 - B配型的移植物中，术后早期观察到移植物中单纯疱疹复发（P = 0.0004）。