Bizer L S
Am Surg. 1984 Oct;50(10):524-9.
Portal hypertension related to hepatic cirrhosis produces significant alterations in portal blood flow, pressures, blood volume, and systemic hemodynamics. These alterations decrease portal blood flow to the hepatic parenchyma with measurable decreases in hepatic parenchymal function. The development of bleeding esophagogastric varices and the methods used to treat this complication are all unsatisfactory either in the short or long term. Portal systemic shunting, in particular, further decreases portal flow to the liver with deleterious effects on hepatic cellular function. Pharmacologic methods to decrease the risk of variceal bleeding are the most promising recent development in the care of these patients.
与肝硬化相关的门静脉高压会导致门静脉血流、压力、血容量和全身血流动力学发生显著改变。这些改变会减少进入肝实质的门静脉血流，导致肝实质功能出现可测量的下降。食管胃静脉曲张出血的发生以及用于治疗该并发症的方法，无论在短期还是长期都不尽人意。特别是门体分流会进一步减少肝脏的门静脉血流，对肝细胞功能产生有害影响。降低静脉曲张出血风险的药物治疗方法是这些患者护理中最有前景的最新进展。
